Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

It is now established that most of the approximately 800 G-protein-coupled receptors (GPCRs) are regulated by phosphorylation in a process that results in the recruitment of arrestins, leading to receptor desensitization and the activation of arrestin-dependent processes. This generalized view of GPCR regulation, however, does not provide an adequate mechanism for the control of tissue-specific...

Context Specific Next Location Prediction

Location-Specific Amenities, Equilibrium, and Constraints on Location Choices

This research considers how preferences for location-specific attributes might constrain migration destination choices. In particular, if, at any given time, most people are consuming their desired location-specific attributes, then unwillingness to give up these attributes may influence the decision to migrate. For those who migrate, these desired attributes might significantly constrain the l...

Location of type-specific antigens in calf rotaviruses.

Rotavirus antisera with and without neutralizing activity to calf rotavirus were compared for their ability to agglutinate calf rotavirus particles with and without an outer capsid layer. Particles without the outer capsid layer were agglutinated by antisera with immunofluorescent antibody activity and by antisera with immunofluorescent antibody and neutralizing activity. Particles with the out...

Cell-type specific calcium signalling in a Drosophila epithelium.

Calcium is a ubiquitous second messenger that plays a critical role in both excitable and non-excitable cells. Calcium mobilisation in identified cell types within an intact renal epithelium, the Drosophila melanogaster Malpighian tubule, was studied by GAL4-directed expression of an aequorin transgene. CAP2b, a cardioactive neuropeptide that stimulates fluid secretion by a mechanism involving ...